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Using a towel wrap or a cat bag is the safest method for restraining a cat for examination. This technique provides a secure way to manage the cat while minimizing stress for both the animal and the handler. A towel wrap allows for a gentle but firm hold, reducing the risk of the cat escaping or injuring itself or the person handling it. The wrap also helps create a comforting environment for the cat, as it can feel more secure and less exposed.

Moreover, a cat bag is designed specifically for veterinary use and has the added benefit of allowing easy access to the cat for performing examinations without the need for excessive handling. Both methods help in controlling the cat's movements effectively, which is essential during an examination.

In contrast, holding a cat firmly by the scruff may not be appropriate for every cat, as it can be perceived as threatening or uncomfortable. Muzzling a cat before handling could increase stress levels and may not be necessary unless the cat shows aggressive tendencies. Placing a cat in a small cage can be helpful for transport but does not provide the immediate control and examination access needed for a thorough assessment. Therefore, the towel wrap or cat bag approach is more effective for safe and stress-free examinations.